Kesselring, Rebecca and Fichtner-Feigl, Stefan (2012) Immune responses triggering colitis and colitis-associated carcinoma. LANGENBECKS ARCHIVES OF SURGERY, 397 (4). pp. 527-533. ISSN 1435-2443
Full text not available from this repository. (Request a copy)Abstract
Inflammatory bowel diseases compromise of two forms of chronic intestinal inflammatory disorders: Crohn's disease and ulcerative colitis. Both forms of inflammatory bowel disease result from inappropriate inflammatory responses to the intestinal microbiota, but have different underlying immune responses. The connection between inflammation and cancer has long been established and longstanding inflammatory bowel diseases are an important risk factor for developing colorectal cancer. Colitis-associated colorectal cancer pathogenesis is highly influenced by specific inflammatory processes during inflammatory bowel disease. This article reviews the immunological responses affecting Crohn's disease and ulcerative colitis as well as the linkage of inflammatory bowel disease to the development of colitis-associated cancer. Finally, we discuss the prospects of using new research efforts to devise new immunotherapeutic approaches.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; NK-T-CELLS; NOD-LIKE RECEPTORS; ULCERATIVE-COLITIS; TUMOR IMMUNOSURVEILLANCE; INTESTINAL INFLAMMATION; COLORECTAL-CANCER; CROHNS-DISEASE; IL-13; TUMORIGENESIS; Colitis; Colitis-associated cancer; Immunology; Crohn's disease; Ulcerative colitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 11 May 2020 10:17 |
| Last Modified: | 11 May 2020 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18988 |
Actions (login required)
 |
View Item |
