Pfeifer, Eva and Polz, Johannes and Maennel, Daniela N. and Mostboeck, Sven (2012) Inflammation augments the development of experimental glomerulonephritis by accelerating proteinuria and enhancing mortality. EUROPEAN CYTOKINE NETWORK, 23 (1). pp. 12-14. ISSN 1148-5493,
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Proteinuria represents a parameter for a damaged filtration capacity of the kidney. We investigated how inflammation influences the development of experimental, immune complex-mediated glomerulonephritis by monitoring proteinuria. Mice pre-treated with LPS or TNF, one day before induction of glomerulonephritis, excreted high levels of protein in the urine immediately after the induction of glomerulonephritis, in contrast to non-treated mice where proteinuria increased steadily after day 3. Protein levels in the urine of pre-treated mice remained elevated over the 15-day observation time. The severity of proteinuria at later times correlated with the degree of tissue pathology and mortality in individual mice. Pre-treatment with inflammatory agents accelerated the development of proteinuria and induced more severe kidney damage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPERIMENTAL CRESCENTIC GLOMERULONEPHRITIS; NECROSIS-FACTOR-ALPHA; GLOMERULAR INJURY; TNF-ALPHA; NEPHRITIS; RECEPTOR; kidney; inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 May 2020 10:07 |
| Last Modified: | 18 May 2020 10:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19081 |
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