Pattaro, Cristian and Koettgen, Anna and Teumer, Alexander and Garnaas, Maija and Boeger, Carsten A. and Fuchsberger, Christian and Olden, Matthias and Chen, Ming-Huei and Tin, Adrienne and Taliun, Daniel and Li, Man and Gao, Xiaoyi and Gorski, Mathias and Yang, Qiong and Hundertmark, Claudia and Foster, Meredith C. and O'Seaghdha, Conall M. and Glazer, Nicole and Isaacs, Aaron and Liu, Ching-Ti and Smith, Albert V. and O'Connell, Jeffrey R. and Struchalin, Maksim and Tanaka, Toshiko and Li, Guo and Johnson, Andrew D. and Gierman, Hinco J. and Feitosa, Mary and Hwang, Shih-Jen and Atkinson, Elizabeth J. and Lohman, Kurt and Cornelis, Marilyn C. and Johansson, Asa and Toenjes, Anke and Dehghan, Abbas and Chouraki, Vincent and Holliday, Elizabeth G. and Sorice, Rossella and Kutalik, Zoltan and Lehtimaeki, Terho and Esko, Tonu and Deshmukh, Harshal and Ulivi, Sheila and Chu, Audrey Y. and Murgia, Federico and Trompet, Stella and Imboden, Medea and Kollerits, Barbara and Pistis, Giorgio and Harris, Tamara B. and Launer, Lenore J. and Aspelund, Thor and Eiriksdottir, Gudny and Mitchell, Braxton D. and Boerwinkle, Eric and Schmidt, Helena and Cavalieri, Margherita and Rao, Madhumathi and Hu, Frank B. and Demirkan, Ayse and Oostra, Ben A. and de Andrade, Mariza and Turner, Stephen T. and Ding, Jingzhong and Andrews, Jeanette S. and Freedman, Barry I. and Koenig, Wolfgang and Illig, Thomas and Doering, Angela and Wichmann, H. -Erich and Kolcic, Ivana and Zemunik, Tatijana and Boban, Mladen and Minelli, Cosetta and Wheeler, Heather E. and Igl, Wilmar and Zaboli, Ghazal and Wild, Sarah H. and Wright, Alan F. and Campbell, Harry and Ellinghaus, David and Nothlings, Ute and Jacobs, Gunnar and Biffar, Reiner and Endlich, Karlhans and Ernst, Florian and Homuth, Georg and Kroemer, Heyo K. and Nauck, Matthias and Stracke, Sylvia and Voelker, Uwe and Voelzke, Henry and Kovacs, Peter and Stumvoll, Michael and Magi, Reedik and Hofman, Albert and Uitterlinden, Andre G. and Rivadeneira, Fernando and Aulchenko, Yurii S. and Polasek, Ozren and Hastie, Nick and Vitart, Veronique and Helmer, Catherine and Wang, Jie Jin and Ruggiero, Daniela and Bergmann, Sven and Kaehoenen, Mika and Viikari, Jorma and Nikopensius, Tiit and Province, Michael and Ketkar, Shamika and Colhoun, Helen and Doney, Alex and Robino, Antonietta and Giulianini, Franco and Kraemer, Bernhard K. and Portas, Laura and Ford, Ian and Buckley, Brendan M. and Adam, Martin and Thun, Gian-Andri and Paulweber, Bernhard and Haun, Margot and Sala, Cinzia and Metzger, Marie and Mitchell, Paul and Ciullo, Marina and Kim, Stuart K. and Vollenweider, Peter and Raitakari, Olli and Metspalu, Andres and Palmer, Colin and Gasparini, Paolo and Pirastu, Mario and Jukema, J. Wouter and Probst-Hensch, Nicole M. and Kronenberg, Florian and Toniolo, Daniela and Gudnason, Vilmundur and Shuldiner, Alan R. and Coresh, Josef and Schmidt, Reinhold and Ferrucci, Luigi and Siscovick, David S. and van Duijn, Cornelia M. and Borecki, Ingrid and Kardia, Sharon L. R. and Liu, Yongmei and Curhan, Gary C. and Rudan, Igor and Gyllensten, Ulf and Wilson, James F. and Franke, Andre and Pramstaller, Peter P. and Rettig, Rainer and Prokopenko, Inga and Witteman, Jacqueline C. M. and Hayward, Caroline and Ridker, Paul and Parsa, Afshin and Bochud, Murielle and Heid, Iris M. and Goessling, Wolfram and Chasman, Daniel I. and Kao, W. H. Linda and Fox, Caroline S. (2012) Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function. PLOS GENETICS, 8 (3): e1002584. ISSN 1553-7404,
Full text not available from this repository. (Request a copy)Abstract
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLOMERULAR-FILTRATION-RATE; GENE-EXPRESSION; SERUM CREATININE; COLLABORATIVE METAANALYSIS; HIGHER ALBUMINURIA; DISEASE; ZEBRAFISH; ORGANIZATION; BRAIN; GFR; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 May 2020 04:51 |
| Last Modified: | 25 May 2020 04:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19084 |
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