Berner, Arne and Reichert, Johannes C. and Mueller, Michael B. and Zellner, Johannes and Pfeifer, Christian and Dienstknecht, Thomas and Nerlich, Michael and Sommerville, Scott and Dickinson, Ian C. and Schuetz, Michael A. and Fuechtmeier, Bernd (2012) Treatment of long bone defects and non-unions: from research to clinical practice. CELL AND TISSUE RESEARCH, 347 (3). pp. 501-519. ISSN 0302-766X, 1432-0878
Full text not available from this repository. (Request a copy)Abstract
The treatment of long bone defects and non-unions is still a major clinical and socio-economical problem. In addition to the non-operative therapeutic options, such as the application of various forms of electricity, extracorporeal shock wave therapy and ultrasound therapy, which are still in clinical use, several operative treatment methods are available. No consensus guidelines are available and the treatments of such defects differ greatly. Therefore, clinicians and researchers are presently investigating ways to treat large bone defects based on tissue engineering approaches. Tissue engineering strategies for bone regeneration seem to be a promising option in regenerative medicine. Several in vitro and in vivo studies in small and large animal models have been conducted to establish the efficiency of various tissue engineering approaches. Neverthelsss, the literature still lacks controlled studies that compare the different clinical treatment strategies currently in use. However, based on the results obtained so far in diverse animal studies, bone tissue engineering approaches need further validation in more clinically relevant animal models and in clinical pilot studies for the translation of bone tissue engineering approaches into clinical practice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; PLATELET-RICH PLASMA; MARROW STROMAL CELLS; TIBIAL-SHAFT FRACTURES; FAILED EXTERNAL FIXATION; MORPHOGENETIC PROTEIN; SEGMENTAL DEFECTS; IN-VITRO; PROGENITOR CELLS; OSTEOSEPTOCUTANEOUS FLAP; Bone defect; Bone tissue engineering; Clinical studies; Orthopaedic research |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 11 May 2020 08:37 |
| Last Modified: | 11 May 2020 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19094 |
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