Schlossmann, Jens and Schinner, Elisabeth (2012) cGMP becomes a drug target. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 385 (3). pp. 243-252. ISSN 0028-1298, 1432-1912
Full text not available from this repository. (Request a copy)Abstract
Cyclic guanosine 3',5'-monophosphate (cGMP) serves as a second messenger molecule, which regulates pleiotropic cellular functions in health and disease. cGMP is generated by particulate or soluble guanylyl cyclases upon stimulation with natriuretic peptides or nitric oxide, respectively. Furthermore, the cGMP concentration is modulated by cGMP-degrading phosphodiesterases. Several targets of cGMP are utilized to effect its various cellular functions. These effector molecules comprise cGMP-dependent protein kinases, ion channels, and phosphodiesterases. During the last decade, it emerged that cGMP is a novel drug target for the treatment of pulmonary and cardiovascular disorders. In this respect, several drugs were developed, which are now in clinical phase studies for, e.g., pulmonary hypertension or cardiovascular diseases. These new drugs act NO-independently with/without heme on soluble guanylyl cyclases or induce subtypes of particular guanylyl cyclases and thereby lead to new therapeutic concepts and horizons. In this regard, the fifth cGMP meeting held in June 2011 in Halle, Germany, comprised the new therapeutic challenges with the novel functional and structural concepts of cGMP generating and effector molecules. This report summarizes the new data on molecular mechanisms, (patho)physiological relevance, and therapeutic potentials of the cGMP signaling system that were presented at this meeting.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEPENDENT PROTEIN-KINASE; SOLUBLE GUANYLYL CYCLASE; CYCLIC-GMP; BLOOD-PRESSURE; CRYSTAL-STRUCTURE; COMMON VARIANTS; PULMONARY-HYPERTENSION; NATRIURETIC-PEPTIDE; CARDIAC-HYPERTROPHY; HYDROGEN-SULFIDE; cGMP; Guanylyl cyclases; Guanylate cyclases; cGMP-dependent protein kinase; sGC stimulator; sGC activator; Natriuretic peptides; Pulmonary hypertension |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 11 May 2020 06:16 |
| Last Modified: | 11 May 2020 06:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19190 |
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