Haubner, Frank and Ohmann, Elisabeth and Mueller-Vogt, Uwe and Kummer, Peter and Strutz, Juergen and Gassner, Holger (2012) Effects of Botulinum Toxin A on Cytokine Synthesis in a Cell Culture Model of Cutaneous Scarring. ARCHIVES OF FACIAL PLASTIC SURGERY, 14 (2). pp. 122-126. ISSN 1521-2491,
Full text not available from this repository. (Request a copy)Abstract
Objective: To evaluate possible botulinum toxin A effects in a cell culture model. Methods: In a cell culture model with dermal fibroblasts and microvascular endothelial cells, possible botulinum toxin A effects were evaluated. Cell proliferation and cytokine expression were analyzed using viability assays and enzyme-linked immunosorbent assay techniques. Results: Neither cell proliferation nor cytokines and growth factors (interleukin 6, monocyte chemoattractant protein 2, fibroblast growth factor, macrophage colony-stimulating factor, and vascular endothelial growth factor) were affected by botulinum toxin A incubation. Conclusions: The present data do not add evidence to suggest a significant therapeutic role of botulinum toxin A injections for cutaneous wound healing beyond chemoimmobilization. Further studies that include patient-specific cells of hypertrophic scars are required to better understand what role botulinum toxin A can play in the treatment of mature scar tissue.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACIAL WOUNDS; IN-VIVO; GROWTH; MICE; IL-6; GENE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2020 06:59 |
| Last Modified: | 19 May 2020 06:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19203 |
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