Wiggermann, Philipp and Puls, Ralf and Vasilj, Andrej and Sieron, Dominik and Schreyer, Andreas G. and Jung, Ernst-Michael and Wawrzynek, Wojciech and Stroszczynski, Christian (2012) Thermal ablation of unresectable liver tumors: Factors associated with partial ablation and the impact on long-term survival. MEDICAL SCIENCE MONITOR, 18 (2). CR88-CR92. ISSN 1643-3750,
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Background: Thermal ablation procedures, including radiofrequency ablation (RFA) or laser-induced interstitial thermotherapy (LITT), are now well established in the treatment of malignant unresectable hepatic tumors. But the impact of partial ablation (PA) on long-term survival following computed tomography (CT)-guided radiofrequency ablation and laser- induced interstitial thermotherapy of unresectable malignant liver lesions and the associated risk factors of PA remain partially unknown. Materials/Methods: This study included 254 liver tumors in 91 consecutive patients (66 men and 25 women; age 60.9 +/- 10.4 years; mean tumor size 25 14 mm [range 5-70 min]) who underwent thermal ablation (RFA or LITT) between January 2000 and December 2007. Mean follow-up period was 21.1 month (range 1-69 months). Survival rate and local progression-free survival (PFS) were calculated for patients with complete ablation (CA) vs. patients with partial ablation (PA) to assess the impact on long-term survival. Results: Median survival after CA was 47 months compared to 25 months after PA (P=0.04). The corresponding 5-year survival rates were 44% vs. 20%. Median PFS for CA was 11 months compared to 7 months for PA (P=0.118). The sole statistically significant risk factor for PA was tumor size (>30 mm; P=0.0003). Sustained complete ablation was achieved in 71% of lesions <30 mm vs. 47% of lesions >30 mm. Conclusions: We conclude that achievement of complete ablation is a highly important predictor of long-term survival and that tumor size is by far the most important predictor of the likelihood of achieving complete ablation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERCUTANEOUS RADIOFREQUENCY ABLATION; HEPATOCELLULAR-CARCINOMA; HEPATIC METASTASES; COLORECTAL-CANCER; 10-YEAR EXPERIENCE; LOCAL RECURRENCE; RISK-FACTORS; RESECTION; CHEMOEMBOLIZATION; MULTICENTER; radiofrequency ablation; laser induced interstitial thermotherapy; liver tumors; liver metastases |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2020 09:13 |
| Last Modified: | 19 May 2020 09:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19249 |
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