Stoehr, C. G. and Stoehr, R. and Hartmann, A. and Hofstaedter, F. and Junker, K. and Blaszyk, H. and Wieland, W. F. and Otto, W. and Denzinger, S. and Walter, Bernhard (2012) Mutational activation of FGFR3: no involvement in the development of renal cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 138 (2). pp. 359-361. ISSN 0171-5216,
Full text not available from this repository. (Request a copy)Abstract
Background Somatic point mutations in the fibroblast growth factor receptor 3 (FGFR3) gene have been identified in certain types of urological cancers, especially urothelial carcinoma of the bladder and the renal pelvis, and could be correlated with a favourable outcome. However, comprehensive data on the FGFR3 mutation status in renal cell carcinoma (RCC) are still missing. Methods In order to investigate a possible role for FGFR3 mutations in renal cell carcinogenesis, we performed a sequence-based mutational analysis of FGFR3 in 238 primary RCC. The cohort obtained the common RCC subtypes including 101 clear cell, 50 papillary and 68 chromophobe RCC specimens. The analysed regions encompassed all FGFR3 point mutations previously described in epithelial tumours and other noncutaneous epithelial malignancies. Results No mutations were detected in any renal tumour type examined, and all cases showed wild-type sequence. Conclusion Our results argue against an involvement of mutational activation of FGFR3 in the development of RCC. A recently described cystic renal dysplasia in a patient with thanatophoric dysplasia type 1 due to a germ line FGFR3 mutation might portend to an involvement of mutational FGFR3 activation in renal cyst formation, but this speculation needs further evaluation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FIBROBLAST-GROWTH-FACTOR; FACTOR RECEPTOR-3 MUTATIONS; FACTOR-I FGF-1; EXPRESSION; CANCERS; DISEASE; BLADDER; Renal cell carcinoma; FGFR3 mutational activation; Tumourigenesis; RCC subtypes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2020 11:14 |
| Last Modified: | 19 May 2020 11:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19281 |
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