Liebisch, Gerhard and Scherer, Max (2012) Quantification of bioactive sphingo- and glycerophospholipid species by electrospray ionization tandem mass spectrometry in blood. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 883. pp. 141-146. ISSN 1570-0232, 1873-376X
Full text not available from this repository. (Request a copy)Abstract
Bioactive glycerophospho- and sphingolipids species are involved in the regulation of numerous biological processes and implicated in the pathophysiology of various diseases. Here we review electrospray ionization tandem mass spectrometric (ESI-MS/MS) methods for the analysis of these bioactive lipid species in blood including lysophosphatidic acid (LPA), lysophosphatidylcholine (LPC), bis(monoacylglycero)phosphate (BMP), ceramide (Cer), sphingosine-1-phosphate (SIP) and sphingosylphosphorylcholine (SPC). Beside direct tandem mass spectrometric and liquid chromatography coupled approaches, we present an overview of concentrations of these bioactive lipids in plasma. The analytical strategies are discussed together with aspects of sample preparation, quantification and sample stability. (C) 2011 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-THROUGHPUT QUANTIFICATION; SEPARATED LIPOPROTEIN FRACTIONS; LYSOPHOSPHATIDIC ACID; QUANTITATIVE-ANALYSIS; POTENTIAL BIOMARKERS; BIOLOGICAL SAMPLES; ESI-MS/MS; PLASMA LYSOPHOSPHOLIPIDS; SHOTGUN LIPIDOMICS; OVARIAN-CANCER; Liquid chromatography tandem mass spectrometry (LC-MS/MS); Lysophospholipids; Lipidomics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2020 11:19 |
| Last Modified: | 19 May 2020 11:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19282 |
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