Poloschek, C. M. and Jaegle, H. (2012) Pharmacological concepts to treat hereditary retinal degenerations. OPHTHALMOLOGE, 109 (2). pp. 112-120. ISSN 0941-293X,
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This article reviews the current pharmacological strategies to treat inherited retinal degeneration. To date there is no causal therapy despite growing knowledge of the particular pathomechanisms. However, treatment is available for complications, such as cystic macular changes and cystoid macular edema. To reduce retinal thickness systemic or topical carboanhydrase inhibitors can be applied and in rare cases combined with steroids when indicated, however reduction of retinal thickness is not always accompanied by improvement of visual acuity. Regular follow-up with optical coherence tomography is required. In some cases, potentially neuroprotective agents (valproic acid, ciliary neurotrophic factor and Ca2+ channel inhibitors) or food supplementation (vitamin A, lutein, synthetic retinoids and decosahexaenoic acid) may have a positive impact on disease progression (e.g. reduction in progression of visual field loss or individual electrophysiological parameters). However, beneficial effects and side effects, e.g. of vitamin A substitution, depend not only on the disease phenotype (such as retinitis pigmentosa) but also on the actual genotype. Furthermore, no data are available regarding the application of pharmaceuticals in the pediatric population.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CYSTOID MACULAR EDEMA; TOPICAL DORZOLAMIDE THERAPY; RECEIVING VITAMIN-A; RETINITIS-PIGMENTOSA; CLINICAL-TRIAL; INTRAVITREAL TRIAMCINOLONE; DOCOSAHEXAENOIC ACID; CONTINUED USE; ACETAZOLAMIDE; LESIONS; Retinitis pigmentosa; Cystoid macular edema; Retinal dystrophies; Ciliary neurotrophic factor; Docosahexaenoic acid |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Abteilung für Pädiatrische Ophthalmologie, Strabismologie und Ophthalmogenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 May 2020 05:30 |
| Last Modified: | 20 May 2020 05:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19299 |
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