Almstetter, Martin F. and Oefner, Peter J. and Dettmer, Katja (2012) Comprehensive two-dimensional gas chromatography in metabolomics. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 402 (6). pp. 1993-2013. ISSN 1618-2642, 1618-2650
Full text not available from this repository. (Request a copy)Abstract
One of the major objectives in metabolomics is the identification of subtle changes in metabolite profiles as affected by genetic or environmental factors. Comprehensive two-dimensional gas chromatography (GC x GC) hyphenated to a fast-acquisition mass spectrometer is a well-established analytical technique to study the composition of complex samples due to its enhanced separation capacity, sensitivity, peak resolution, and reproducibility. This review reports applications of GC x GC to metabolomics studies of sample of different types (biofluid, cells, tissue, bacteria, yeast, plants), and discusses its advantages and limitations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FLIGHT-MASS-SPECTROMETRY; METHYLOBACTERIUM-EXTORQUENS AM1; GC-TOFMS DATA; PARALLEL FACTOR-ANALYSIS; X GC; SYSTEMS BIOLOGY; CHLAMYDOMONAS-REINHARDTII; AMINO-ACIDS; CHEMOMETRIC ANALYSIS; FUNCTIONAL GENOMICS; Metabolomics; Metabolite profiling; Metabolic fingerprinting; Comprehensive two-dimensional gas chromatography |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 May 2020 09:04 |
| Last Modified: | 08 May 2020 09:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19303 |
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