Hutchinson, James A. and Riquelme, Paloma and Geissler, Edward K. (2012) Human regulatory macrophages as a cell-based medicinal product. CURRENT OPINION IN ORGAN TRANSPLANTATION, 17 (1). pp. 48-54. ISSN 1087-2418
Full text not available from this repository. (Request a copy)Abstract
Purpose of review To consolidate our basic scientific and technological appreciation of human regulatory macrophages (M reg) as a cell-based medicinal product for use as an adjunct immunosuppressive therapy in organ transplantation. Recent findings Building on the original observation that crude preparations of IFN-g-stimulated allogeneic macrophages prolong allograft survival in experimental animals, we have arrived at a detailed understanding of the derivation, phenotype and T-cell-suppressive potential of a population of in-vitro-derived human macrophages, which have been designated M regs. This basic scientific knowledge has inspired methodological advances in M reg manufacture, leading to a purer and more homogeneous cell product. In turn, cells produced by these improved protocols have been applied in the clinic, so completing a cycle of technological development. Studying the migration and physiological impact of M reg administration in patients provides a measure of reassurance that the procedure is well tolerated. Cutting-edge strategies to assess the immunological status of solid organ transplant recipients allow the biological effects of M reg treatment to be monitored. Summary A view of the human M reg as a novel, stringently defined medicinal product is presented, opening exciting possibilities for its future investigation as a therapy in solid organ transplantation and beyond.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACCEPTANCE-INDUCING-CELLS; RENAL-TRANSPLANTATION; T-CELLS; BLOOD MONOCYTES; TOLERANCE; THERAPY; PREVENTION; RECIPIENTS; INDUCTION; REJECTION; cell therapy; immunosuppression; regulatory macrophage |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 May 2020 09:25 |
| Last Modified: | 08 May 2020 09:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19330 |
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