Ellinger, Joerg and Kahl, Philip and von der Gathen, Johannes and Heukamp, Lukas C. and Guetgemann, Ines and Walter, Bernhard and Hofstaedter, Ferdinand and Bastian, Patrick J. and von Ruecker, Alexander and Mueller, Stefan C. and Rogenhofer, Sebastian (2012) Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer. CANCER INVESTIGATION, 30 (2). pp. 92-97. ISSN 0735-7907,
Full text not available from this repository. (Request a copy)Abstract
Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MODIFICATIONS PREDICT PROGNOSIS; CPG ISLAND HYPERMETHYLATION; CELL CARCINOMA; POLYCOMB; PROGRESSION; RISK; EZH2; TRIMETHYLATION; RECURRENCE; BREAST; Histone; Methylation; H3K27; Prostate cancer; Epigenetics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 May 2020 07:10 |
| Last Modified: | 20 May 2020 07:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19337 |
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