Combes, Alain and Bacchetta, Matthew and Brodie, Daniel and Mueller, Thomas and Pellegrino, Vince (2012) Extracorporeal membrane oxygenation for respiratory failure in adults. CURRENT OPINION IN CRITICAL CARE, 18 (1). pp. 99-104. ISSN 1070-5295
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Purpose of review This article reviews case series and trials that evaluated extracorporeal membrane oxygenation (ECMO) for respiratory failure and describes patient and circuit management in the modern era of ECMO support. Recent findings In recent years, pivotal progress has been made in the conception and construction of ECMO circuits. They are now simpler, safer, require less anticoagulation and are associated with fewer bleeding complications. The encouraging results of the efficacy and economic assessment of conventional ventilatory support versus ECMO for severe adult respiratory failure (CESAR) trial performed in the United Kingdom and good outcomes of patients who received ECMO as rescue therapy during the recent H1N1 influenza pandemic, in which the latest generation of ECMO technology was used, reignited interest in ECMO for severe acute respiratory distress syndrome (ARDS). Summary The latest generation of ECMO systems is more biocompatible, better performing and longer lasting. Although recent studies suggested that veno-venous ECMO might improve the outcomes of patients with ARDS, indications for ECMO use remain uncertain. Future trials of ECMO for severe ARDS should strictly control for standard-of-care mechanical ventilation strategies in the control group and early transportation on ECMO for patients in the intervention arm.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 2009 INFLUENZA A(H1N1); ACUTE LUNG INJURY; RANDOMIZED CONTROLLED-TRIAL; END-EXPIRATORY PRESSURE; DISTRESS-SYNDROME; LIFE-SUPPORT; SUFFICIENT EVIDENCE; GAS-EXCHANGE; CO2 REMOVAL; VENTILATION; acute respiratory distress syndrome; extracorporeal membrane oxygenation; mechanical ventilation; review article |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 May 2020 09:29 |
| Last Modified: | 08 May 2020 09:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19343 |
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