Bulajic, Milutin and Panic, Nikola and Stimec, Bojan and Isaksson, Bengt and Jesenofsky, Ralf and Schneider-Brachert, Wulf and Lohr, Johannes-Matthias (2012) PCR in Helicobacter spp. diagnostic in extragastric malignancies of digestive system. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 24 (2). pp. 117-125. ISSN 0954-691X, 1473-5687
Full text not available from this repository. (Request a copy)Abstract
Recognition of Helicobacter pylori as an important factor in genesis of gastric adenocarcinoma lead to a large number of studies concerning potential role of Helicobacter spp. in the development of extragastric digestive malignancies. The serological studies indicated possible localizations in the digestive system being from interest in enlightening Helicobacter spp. carcinogenic potential. The PCR obtruded itself as a gold standard in proving existence of actual correlation. In this review, the authors have examined studies conducted in the last 10 years examining Helicobacter spp. correlation with extragastric digestive carcinogenesis. Studies have been observed in four groups referring to hepatic carcinoma, bile duct cancer, pancreatic cancer, and colon cancer. The results of these researches have shown that there is a strong correlation between Helicobacter spp. colonization and primary liver tumors as well as bile duct tumors, whereas conclusions made by authors examining pancreatic cancer are contradictory and demands further investigation. No correlation between Helicobacter spp. and colon cancer have been proven. The PCR subtype most widely used in studies included in this review was nested PCR, whereas genes targeted most frequently for amplification are 16S rDNA of Helicobacter spp. and UreA gene or cagA gene of H. pylori. During the last 10 years PCR has proven itself as a sovereign method for Helicobacter spp. diagnostic in extragastric organs in the digestive system. Knowledge and experiences obtained in this domain could be encouraging for researchers in analogous fields of interest. Eur J Gastroenterol Hepatol 24:117-125 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; PYLORI INFECTION; AUTOIMMUNE PANCREATITIS; COLORECTAL-CARCINOMA; COLONIC ADENOMAS; GASTRIC-CANCER; LIVER SAMPLES; DNA; ASSOCIATION; bile duct cancer; colon cancer; Helicobacter spp.; hepatocellular carcinoma; pancreatic cancer; PCR |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 May 2020 08:57 |
| Last Modified: | 08 May 2020 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19345 |
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