Shao, Zhe and Schaeffler, Andreas and Hamer, Okka and Dickopf, Judith and Goetz, Andrea and Landfried, Karin and Voelk, Markus and Kopp, Andrea and Herfarth, Hans and Karrasch, Thomas and Bruennler, Tanja and Koh, Liang Kai and Buechler, Christa and Schwarz, Herbert (2012) Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 92 (1). pp. 1-6. ISSN 0014-4800, 1096-0945
Full text not available from this repository. (Request a copy)Abstract
The progression of acute pancreatitis to necrotizing pancreatitis which often results in high morbidity and mortality is difficult to predict Here we report that serum concentrations of sCD137 are increased in patients with acute pancreatitis. Admission levels and 10-day median sCD137 levels positively correlate with markers of biliary pancreatitis and the 10-day sCD137 median is significantly higher in metabolic than in alcoholic pancreatitis. Serum concentrations of sCD137 at time of admission and the 10-day median of sCD137 correlate with the Ranson and APACHE II disease scores but not with the radiological Balthazar and Schroeder scores that reflect pancreatic and peripancreatic necrosis. Further, sCD137 levels correlate with the probability of complications and lethality. The association of sCD137, a product of activated T cells, with the severity of acute pancreatitis suggests that T cells contribute to the pathogenesis of acute pancreatitis. (C) 2011 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Peripancreatic necrosis; Acute pancreatitis; Soluble CD137 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 May 2020 08:43 |
| Last Modified: | 20 May 2020 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19353 |
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