Spies, Cornelia M. and Straub, Rainer H. and Buttgereit, Frank (2012) Energy metabolism and rheumatic diseases: from cell to organism. ARTHRITIS RESEARCH & THERAPY, 14 (3): 216. ISSN 1478-6354, 1478-6362
Full text not available from this repository. (Request a copy)Abstract
In rheumatic and other chronic inflammatory diseases, high amounts of energy for the activated immune system have to be provided and allocated by energy metabolism. In recent time many new insights have been gained into the control of the immune response through metabolic signals. Activation of immune cells as well as reduced nutrient supply and hypoxia in inflamed tissues cause stimulation of glycolysis and other cellular metabolic pathways. However, persistent cellular metabolic signals can promote ongoing chronic inflammation and loss of immune tolerance. On the organism level, the neuroendocrine immune response of the hypothalamic-pituitary adrenal axis and sympathetic nervous system, which is meant to overcome a transient inflammatory episode, can lead to metabolic disease sequelae if chronically activated. We conclude that, on cellular and organism levels, a prolonged energy appeal reaction is an important factor of chronic inflammatory disease etiology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC-LUPUS-ERYTHEMATOSUS; HYPOXIA-INDUCIBLE FACTOR; T-CELLS; INFLAMMATORY DISEASES; NEUTROPHIL SURVIVAL; PROTEIN-SYNTHESIS; SYNOVIAL FLUIDS; TISSUE HYPOXIA; ACTIVATION; ARTHRITIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 May 2020 09:31 |
| Last Modified: | 08 May 2020 09:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19388 |
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