Bergler, Tobias and Resch, Markus and Reinhold, Stephan W. and Birner, Christoph and Jungbauer, Carsten G. and Griese, Daniel P. and Schmid, Peter and Banas, Bernhard and Endemann, Dierk (2012) Cyclosporine A Impairs Norepinephrine-Induced Vascular Contractility. KIDNEY & BLOOD PRESSURE RESEARCH, 35 (6). pp. 655-662. ISSN 1420-4096, 1423-0143
Full text not available from this repository. (Request a copy)Abstract
Usage of cyclosporine A (CsA) after kidney transplantation may be associated with development of nephrotoxicity and vasculopathy, but the mechanisms by which CsA causes vascular dysfunction are still under scrutiny. We established a transplantation model and investigated the effect of CsA on vascular contractility with the aid of a pressurized myograph in comparison with control and unilaterally nephrectomized rats. Results were correlated with mRNA expression studies of alpha- and beta-adrenoreceptors, in mesenteric resistance arteries versus the thoracic aorta. Consequences of everolimus on functional properties as well as adrenoreceptor expression were also studied. CsA significantly downregulated expression of mesenteric adrenoreceptors, whereas no effect on aortic adrenoreceptors was seen. Administration of everolimus had no influence on mRNA adrenoreceptor expression in mesenteric resistance arteries. Furthermore, contractile responses of mesenteric resistance arteries to norepinephrine were markedly reduced after treatment with CsA, while there was no difference in contraction by endothelin. Everolimus did not alter the contractility response at all. In summary, norepinephrine-induced, but not endothelin-induced, contractile responses of mesenteric resistance arteries are blunted in CsA-treated rats. This finding was accompanied by a marked downregulation of adrenoreceptors in mesenteric resistance arteries and was limited to the usage of CsA. Copyright (C) 2012 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAT AORTA; SYMPATHETIC ACTIVITY; INDUCED HYPERTENSION; MESENTERIC-ARTERIES; DOWN-REGULATION; NEPHROTOXICITY; RECEPTOR; RELAXATION; ENDOTHELIN; RESPONSES; Adrenoreceptors; Cyclosporine; Endothelin; Norepinephrine; Renal transplantation; Resistance arteries |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 May 2020 05:33 |
| Last Modified: | 22 May 2020 05:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19392 |
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