Wiggermann, P. and Heibl, M. and Niessen, C. and Mueller-Wille, R. and Goessmann, H. and Uller, W. and Poschenrieder, F. and Schreyer, A. G. and Wohlgemuth, W. A. and Stroszczynski, C. and Jung, E. M. (2012) Degradable starch microspheres transarterial chemoembolization (DSM-TACE) of HCC: Dynamic Contrast-Enhanced Ultrasonography (DCE-US) based evaluation of therapeutic efficacy using a novel perfusion software. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 52 (2-4). pp. 123-129. ISSN 1386-0291,
Full text not available from this repository. (Request a copy)Abstract
Purpose: To evaluate therapeutic efficacy of degradable starch microsphere (DSM)-TACE in hepatocellular carcinoma (HCC) using Dynamic Contrast-Enhanced Ultrasonography (DCE-US) based perfusion analysis. Materials and methods: A total of 60 DCE-US examinations were performed in 15 selected patients who underwent DSM-TACE with EmboCept (R) S for the treatment of advanced HCC. DCE-US was performed via i.v. application of ultrasound contrast media before and 24 hours post embolization. In addition DCE-US was performed with i.a. contrast application via the angio-graphic catheter right before and after the embolization. Microcirculation of embolized HCC lesions was quantified using a dedicated perfusion software by two experienced radiologists in consensus. Results: Significant reduction of microvascularization (PE, WiAUC and WiR) was seen right after DSM-TACE and during 24 hour follow-up. Mean PE was 342.22 +/- 97.80 prior to embolization, 59.28 +/- 29.74 post embolization (p = 0.019) and 18.83 +/- 7.03 during follow-up (p <= 0.01). Mean WiAUC was 1103.21 +/- 432.05 prior to embolization 267.69 +/- 151.80 post embolization (p = 0.023) and 105.10 +/- 44.43 during 24 hour follow-up (p <= 0.01). The corresponding values for WiR were 224.91 +/- 57.97 prior-, 38.14 +/- 18.80 post embolization (p = 0.034) and 6.97 +/- 2.68 during follow up (p <= 0.01). Conclusion: In this study, therapeutic efficacy of DSM-TACE in HCC using DCE-US based perfusion analysis could be demonstrated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UNRESECTABLE HEPATOCELLULAR-CARCINOMA; ARTERIAL EMBOLIZATION; ULTRASOUND CEUS; TIME; MICROCIRCULATION; MRI; HCC; DSM-TACE; DCE-US |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 May 2020 07:29 |
| Last Modified: | 22 May 2020 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19408 |
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