Hopf, Susanne and Baeumel, Monika and Gruber, Michael and Bein, Thomas and Creutzenberg, Marcus and Graf, Bernhard and Pawlik, Michael (2012) The Effect of Perchlorate Medication on Point-of-Care Testing. CLINICAL LABORATORY, 58 (9-10). pp. 1067-1070. ISSN 1433-6510,
Full text not available from this repository. (Request a copy)Abstract
Background: To create awareness for mismeasurements of ion-selective electrodes caused by patients' medications and to prevent severe consequences in an intensive care therapy. Case presentation: A 73-year-old woman presented with severe carbimazol-induced toxic epidermal necrolysis. After replacement of carbimazol by sodiumperchlorate, we detected a huge discrepancy in the measurement of ionised calcium by two different Point-of-Care (POCT) systems. While Siemens Rapidlab 865 (R) showed a severe hypocalcemia at all times, the Radiometer 600 (R) system first presented a severe hypercalcemia and, in the course of the following days, also a hypocalcemia but with significantly (p < 10 to the -45) higher values than the Rapidlab system. Furthermore, the POCT systems detected a pscudohypocalcemia at times where we think there was a normo- or even hypercalcemia which led to incorrect therapy with excessive substitution of ionised calcium. Conclusions: The substance sodiumperchlorate, which is well established in Europe for hyperthyreosis therapy, caused malfunctions of analyses of ionised calcium by POCT systems. (Clin. Lab. 2012;58:1067-1070. DOT: 10.7754/Clin.Lab.2012.111221)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROLYSIS LYELLS-SYNDROME; Sodiumperchlorate; POCT; ionised calcium; hypercalcemia; pseudohypocalcemia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 May 2020 04:38 |
| Last Modified: | 26 May 2020 04:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19421 |
Actions (login required)
 |
View Item |
