Gonzales, Fernanda Pereira and Maisch, Tim (2012) Photodynamic inactivation for controlling Candida albicans infections. FUNGAL BIOLOGY, 116 (1). pp. 1-10. ISSN 1878-6146
Full text not available from this repository. (Request a copy)Abstract
Antimicrobial photodynamic therapy (APDT) combines a non-toxic dye, termed photosensitizer, which is activated by visible light of appropriate wavelength which will produce reactive oxygen species (ROS). These ROS will react with cellular components inducing oxidative processes, leading to cell death. A wide range of microorganisms, have already showed susceptibility to APDT. Therefore, this treatment might consist in an alternative for the management of fungal infections that is mainly caused by biofilms, since they respond poorly to conventional antibiotics and may play a role in persistent infections. Biofilms are the leading cause of microbial infections in humans, thus representing a serious problem in health care. Candida albicans is the main type of fungi able to form biofilms, which cause superficial skin and mucous membrane infections as well as deep-seated mycoses, particularly in immunocompromised patients. In these patients, invasive infections are often associated with high morbidity and mortality. Furthermore, the increase in antifungal resistance has decreased the efficacy of conventional therapies. Treatments are time-consuming and thus demanding on health care budgets. Additionally, current antifungal drugs only have a limited spectrum of action and toxicity. The use of APDT as an antimicrobial topical agent against superficial and cutaneous diseases represents an effective method for eliminating microorganisms. (C) 2011 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIMICROBIAL CHEMOTHERAPY PACT; PORPHINE TETRA TOSYLATE; BIOFILM FORMATION; DRUG-RESISTANCE; ORAL CANDIDOSIS; METHYLENE-BLUE; IN-VITRO; SINGLET OXYGEN; PHOTOSENSITIZED OXIDATION; FUNGAL-INFECTIONS; APDT; Candida albicans; Photodynamic inactivation; ROS; Singlet oxygen; Topical treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 May 2020 06:48 |
| Last Modified: | 08 May 2020 06:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19551 |
Actions (login required)
 |
View Item |
