Kern, K. and Schebesch, K. M. and Schlaier, J. and Hansen, E. and Feigl, G. C. and Brawanski, A. T. and Lange, M. (2012) Levetiracetam compared to phenytoin for the prevention of postoperative seizures after craniotomy for intracranial tumours in patients without epilepsy. JOURNAL OF CLINICAL NEUROSCIENCE, 19 (1). pp. 99-100. ISSN 0967-5868,
Full text not available from this repository. (Request a copy)Abstract
Anticonvulsant drugs are frequently given after craniotomy. Phenytoin (PHI) is the most commonly used agent; levetiracetam (LEV) is a new anticonvulsant drug with fewer side effects. To compare the incidence of seizures in patients receiving either prophylactic PHI or LEV perioperatively, 971 patients undergoing a craniotomy were analysed retrospectively during a 2-year period. PHI was used routinely and LEV was administered when PHI was contraindicated. Seizures documented during the first 7 days after craniotomy were considered. A total of 235 patients were treated with an antiepileptic drug: 81 patients received LEV, and 154 patients, PHI. Two patients receiving LEV (2.5%) and seven receiving PHT (4.5%) had a seizure despite this treatment. No patient had a documented side effect or drug interaction. The data show that LEV may be an alternative option in patients with contraindications to PHI. (C) 2011 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIEPILEPTIC DRUGS; NEUROSURGERY; PROPHYLAXIS; TRIALS; SAFETY; Anticonvulsants; Craniotomy; Levetiracetam; Phenytoin; Seizure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 May 2020 11:21 |
| Last Modified: | 25 May 2020 11:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19566 |
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