Schmid, C. and Schleuning, M. and Tischer, J. and Holler, E. and Haude, K-H and Braess, J. and Haferlach, C. and Baurmann, H. and Oruzio, D. and Hahn, J. and Spiekermann, K. and Schlimok, G. and Schwerdtfeger, R. and Buechner, T. and Hiddemann, W. and Kolb, H-J (2012) Early allo-SCT for AML with a complex aberrant karyotype-results from a prospective pilot study. BONE MARROW TRANSPLANTATION, 47 (1). pp. 46-53. ISSN 0268-3369,
Full text not available from this repository. (Request a copy)Abstract
In AML, a complex aberrant karyotype is associated with poor response to chemotherapy and dismal prognosis. We prospectively studied the concept of allogeneic haematopoietic SCT (HSCT), performed early and regardless of response to induction treatment in patients with complex karyotype AML (CK-AML). The preparative regimen consisted of fludarabine, Ara-C and amsacrine (FLAMSA) chemotherapy, followed by reduced intensity conditioning (RIC) 3 days later. In vivo T-cell depletion by anti-thymocyte globulin was used to protect from early GvHD, and prophylactic donor lymphocyte transfusion was given from day+120 to augment the GvL effect, once tolerance was established. Eighteen consecutive patients with CK-AML (median age: 53 years) received HSCT from related (n=7) or unrelated (n=11) donors. Before FLAMSA-RIC, nine patients each had received one and two induction courses. Stage at start of FLAMSA-RIC was CR/CRi (n=8) or persistent disease (n=10). Following HSCT, 16 patients achieved CR. After a follow-up of 51 months, 11 patients are alive in CR, whereas seven have died in remission (n=3), or from leukaemia (n=4). Cumulative incidence of relapse, non-relapse mortality, acute GvHD >= II and chronic GvHD were 0.222 +/- 0.098, 0.235 +/- 0.104, 0.367 +/- 0.120 and 0.481 +/- 0.123, respectively. Four-year survival from HSCT is 61%. Early HSCT following FLAMSA-RIC may improve the outcome of this unfavourable AML subgroup. Bone Marrow Transplantation (2012) 47, 46-53; doi: 10.1038/bmt.2011.15; published online 28 February 2011
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE MYELOID-LEUKEMIA; STEM-CELL TRANSPLANTATION; COMPLETE REMISSION; POOR-PROGNOSIS; 1ST; DONOR; CYTOGENETICS; ADULTS; CHEMOTHERAPY; DIAGNOSIS; AML; complex aberrant karyotype; early allogeneic SCT; FLAMSA-RIC |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 May 2020 09:13 |
| Last Modified: | 25 May 2020 09:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19575 |
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