Schreml, S. and Meier, R. J. and Albert, M. G. and Seidl, U. and Zeller, V. and Behm, B. and Landthaler, M. and Abels, C. and Babilas, P. (2012) The Impact of 10% alpha-Hydroxy Acid Emulsion on Skin pH. SKIN PHARMACOLOGY AND PHYSIOLOGY, 25 (1). pp. 34-38. ISSN 1660-5527,
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Background/Aims: The effects of a 10% alpha-hydroxy acid (AHA) oil/water (O/W) emulsion on the pH of human skin surface (pH(ss)) and stratum corneum (SC; pH(ss)) were evaluated in vivo. Methods: The AHA O/W emulsion was applied to an area on the volar forearm of male volunteers (n = 12), and then wiped off after 10 min. Prior to application and over the following 3 h, the pH(ss) was measured. We used glass electrode measurements and time domain dual lifetime referencing (tdDLR) with luminescent sensor foils. In another experiment (n = 5), the impact of the AHA O/W emulsion on the pH(sc) gradient was measured by tape stripping of the SC of the volar forearm after application of the AHA O/W emulsion. Results: Compared with pH(ss) values prior to treatment [5.2 +/- 1.7 (tdDLR) or 4.8 +/- 0.5 (electrode)], the pH(ss) was significantly reduced 10 min after application [4.0 +/- 0.3 (tdDLR) or 4.1 +/- 0.1 (electrode)] and the pH(ss) remained significantly reduced over the measurement period of 3 h [after 3 h: 4.4 +/- 0.2 (tdDLR) or 4.5 +/- 0.3 (electrode)]. The AHA O/W emulsion significantly reduced the pH(sc) even down to deep layers of the SC. Conclusion: After a 10-min application time, the 10% AHA O/W emulsion reduces the pH(ss) (for at least 3 h) and pH(sc) in deep layers of the SC. copyright (C) 2011 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STRATUM-CORNEUM; SENSOR; Fruit acid; alpha-Hydroxy acid; Topical application; Cutaneous application |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 May 2020 05:20 |
| Last Modified: | 26 May 2020 05:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19584 |
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