Hilgendorf, Inken and Mueller-Hilke, Brigitte and Kundt, Guenther and Holler, Ernst and Hoffmann, Petra and Edinger, Matthias and Freund, Mathias and Wolff, Daniel (2012) The lack of memory B cells including T cell independent IgM(+) IgD(+) memory B cells in chronic graft-versus host disease is associated with susceptibility to infection. TRANSPLANT INTERNATIONAL, 25 (1). pp. 87-96. ISSN 0934-0874,
Full text not available from this repository. (Request a copy)Abstract
The chronic graft-versus host disease (cGVHD) is associated with a perturbed B cell homeostasis and an increased infection rate. Aiming to determine the impact of lymphocyte subsets on cGVHD, blood samples from 98 patients at least 100 days following allogeneic haematopoietic stem cell transplantation (median 1066 days) were analyzed, serum levels of immunoglobulins measured and the incidence of severe infections retrospectively documented. Absolute CD19(+) B cell counts, including counts of immature (CD10(+) CD38(++) CD20(+) IgM(++)) and transitional (CD10(-) CD38(++) CD20(+) IgM(++)) as well as class switched memory (CD19(+) CD27(+) IgM(-) IgD(-)) B cells in patients with active cGVHD (n = 52) were significantly decreased as compared to those with inactive (n = 18) or without cGVHD (n = 28). In addition, nonclass switched IgM(+) memory B cells (CD19(+) CD27(+) IgM(-) IgD(-)) were absent in patients with cGVHD, but not in patients with inactive (0.4 x 10(6)/l) or without (1.7 x 10(6)/l) cGVHD (both P < 0.001). In line with these results we found significantly decreased IgG levels in patients with cGVHD, which was associated with a significantly higher rate of severe infections in cGVHD patients. Our data underline the close association of diminished B cell counts with cGVHD and the onset of severe infections. The lack of IgM(+) memory B cells in patients with cGVHD may indicate functional asplenia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; MINOR HISTOCOMPATIBILITY ANTIGENS; IMMUNE RECONSTITUTION; FUNCTIONAL ASPLENIA; IGA DEFICIENCY; CHRONIC GVHD; RISK-FACTORS; ANTIBODY; RECIPIENTS; RITUXIMAB; chronic graft-versus host disease; immunoglobulin; infection; lymphocyte; stem cell transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 May 2020 10:23 |
| Last Modified: | 25 May 2020 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19595 |
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