Schmid, Christof and Philipp, Alois and Hilker, Michael and Rupprecht, Leopold and Arlt, Matthias and Keyser, Andreas and Lubnow, Matthias and Mueller, Thomas (2012) Venovenous extracorporeal membrane oxygenation for acute lung failure in adults. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 31 (1). pp. 9-15. ISSN 1053-2498,
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: Acute lung failure (ALF) is an increasing problem that can be treated with veno-venous extracorporeal membrane oxygenation (vv-ECMO). This report summarizes prospectively collected data of an institutional experience with vv-ECMO. METHODS: From January 2007 to December 2010, 176 patients (mean age, 48 +/- 16; range, 14-78 years) with ALF refractory to conventional therapy were supported with vv-ECMO. The general indication for vv-ECMO was a partial oxygen pressure/fraction of inspired oxygen (FIO(2)) < 80 mm Hg under a FIO(2) of 1.0, a positive end-expiratory pressure of 18 cm H(2)O, and refractory respiratory acidosis (pH < 7.25), despite optimization of conservative therapy. RESULTS: All patients underwent peripheral cannulation. In 59 cases, vv-ECMO was placed in another facility with ECMO transport by helicopter or ambulance. The mean vv-ECMO support interval was 12 +/- 9.0 days (range, 1-67 days). During ECMO, 12 patients (7%) could be extubated and stepwise mobilized. Cannula-related complications during long-term support occurred in 14%, which was mostly minor bleeding. Overall survival was 56%: 58 patients (33%) died during mechanical support, and 20 (11%) died after weaning from the system. The best outcome was noted in trauma patients. Risk factors were mainly advanced age and multiorgan failure. CONCLUSION: Modern vv-ECMO is an excellent treatment in patients with severe ALF and should be more liberally used. J Heart Lung Transplant 2012;31:9-15 (C) 2012 International Society for Heart and Lung Transplantation. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY-DISTRESS-SYNDROME; LIFE-SUPPORT; GAS-EXCHANGE; INJURY; SYSTEM; SHOCK; acute lung failure; mechanical lung support; acute respiratory distress syndrome (ARDS); lung transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 May 2020 10:44 |
| Last Modified: | 25 May 2020 10:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19613 |
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