Kreutz, Marina and Karrer, Sigrid and Hoffmann, Petra and Gottfried, Eva and Szeimies, Rolf-Markus and Hahn, Joachim and Edinger, Matthias and Landthaler, Michael and Andreesen, Reinhard and Merad, Miriam and Holler, Ernst (2012) Whole-Body UVB Irradiation during Allogeneic Hematopoietic Cell Transplantation Is Safe and Decreases Acute Graft-versus-Host Disease. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132 (1). pp. 179-187. ISSN 0022-202X,
Full text not available from this repository. (Request a copy)Abstract
Depletion of host Langerhans cells (LCs) prevents cutaneous graft-versus-host disease (GvHD) in mice. We analyzed whether UVB irradiation is tolerated during the course of human allogeneic hematopoietic cell transplantation and whether depletion of LCs by broadband UVB could improve GvHD outcome. A total of 17 patients received six whole-body UVB irradiations with 75% of the individually determined minimal erythemal dose after conditioning with a reduced intensity protocol. LCs, dermal dendritic cells (DCs), and macrophages were analyzed before and after UVB irradiation by immunohistochemical analysis. Circulating blood cells and serum factors were analyzed in parallel. In striking contrast to previous data, our irradiation protocol was well tolerated in all patients. UVB treatment decreased the number of LCs and also affected dermal DCs. UVB-treated patients also had significantly higher 25-hydroxyvitamin D3 serum levels and higher numbers of circulating CD4+ FoxP3+ regulatory T cells. Strikingly, nine out of nine patients with complete LC depletion (<1 LC per field) developed only grade I GvHD or no GvHD up to day 100. Our results strongly suggest that prophylactic UVB irradiation post transplant is safe and should be further explored as a clinical strategy to prevent acute (skin) GvHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; REGULATORY T-CELLS; EPIDERMAL LANGERHANS CELLS; CONTACT HYPERSENSITIVITY; INDUCED IMMUNOSUPPRESSION; DENDRITIC CELLS; PREVENTS; SKIN; CD4(+)CD25(+); INDUCTION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 May 2020 13:42 |
| Last Modified: | 25 May 2020 13:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19653 |
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