Ferrara, James L. M. and Harris, Andrew C. and Greenson, Joel K. and Braun, Thomas M. and Holler, Ernst and Teshima, Takanori and Levine, John E. and Choi, Sung W. J. and Huber, Elisabeth and Landfried, Karin and Akashi, Koichi and Vander Lugt, Mark and Reddy, Pavan and Chin, Alice and Zhang, Qing and Hanash, Samir and Paczesny, Sophie (2011) Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. BLOOD, 118 (25). pp. 6702-6708. ISSN 0006-4971,
Full text not available from this repository. (Request a copy)Abstract
There are no plasma biomarkers specific for GVHD of the gastrointestinal (GI) tract, the GVHD target organ most associated with nonrelapse mortality (NRM) following hematopoietic cell transplantation (HCT). Using an unbiased, large-scale, quantitative proteomic discovery approach to identify candidate biomarkers that were increased in plasma from HCT patients with GI GVHD, 74 proteins were increased at least 2-fold; 5 were of GI origin. We validated the lead candidate, REG3 alpha, by ELISA in samples from 1014 HCT patients from 3 transplantation centers. Plasma REG3 alpha concentrations were 3-fold higher in patients at GI GVHD onset than in all other patients and correlated most closely with lower GI GVHD. REG3 alpha concentrations at GVHD onset predicted response to therapy at 4 weeks, 1-year NRM, and 1-year survival (P < .001). In a multivariate analysis, advanced clinical stage, severe histologic damage, and high REG3 alpha concentrations at GVHD diagnosis independently predicted 1-year NRM, which progressively increased with higher numbers of onset risk factors present: 25% for patients with 0 risk factors to 86% with 3 risk factors present (P < .001). REG3 alpha is a plasma biomarker of GI GVHD that can be combined with clinical stage and histologic grade to improve risk stratification of patients. (Blood. 2011;118(25):6702-6708)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PANCREATITIS-ASSOCIATED PROTEIN; ACUTE GVHD; MARROW-TRANSPLANTATION; CELL TRANSPLANTATION; PANETH CELLS; SERUM; EXPRESSION; DIAGNOSIS; PATHOLOGY; BACTERIA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 May 2020 10:00 |
| Last Modified: | 26 May 2020 10:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19674 |
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