Diagnosis, management and possibilities to prevent parvovirus B19 infection in pregnancy

Plentz, Annelie and Modrow, Susanne (2011) Diagnosis, management and possibilities to prevent parvovirus B19 infection in pregnancy. FUTURE VIROLOGY, 6 (12). pp. 1435-1450. ISSN 1746-0794, 1746-0808

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Abstract

Human parvovirus B19 (B19V) infection in pregnancy can cause severe fetal anemia and nonimmune hydrops fetalis, which may be associated with spontaneous abortion and fetal death. Approximately 30-40% of women of child-bearing age are not immune to B19V infection. The risk to fetal life is particularly high if maternal infection occurs during the first 20 weeks of gestation. In this article we intend to give an overview on the molecular biology, epidemiology and management of B19V infection during pregnancy. These data will be combined with an assessment of the clinical situation of the infected fetus and the possibilities for avoiding and/or preventing B19V infection in pregnant women. Currently B19V infection is the causative agent of one of the most frequently occurring infectious complications in pregnancy that endangers fetal life, and so the necessity to develop a preventive vaccine is discussed.

Item Type: Article
Uncontrolled Keywords: INTRAUTERINE FETAL-DEATH; REAL-TIME PCR; CELLULAR TRANSCRIPTION FACTORS; INTRAVENOUS IMMUNE GLOBULIN; NONSTRUCTURAL NS1 PROTEIN; HUMAN BOCAVIRUS INFECTION; VP1 UNIQUE REGION; BONE-MARROW; HYDROPS-FETALIS; 5TH DISEASE; fetal infection; nonimmune hydrops fetalis; parvovirus B19; pregnancy; spontaneous miscarriage; vaccine development
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Depositing User: Petra Gürster
Date Deposited: 06 May 2020 11:01
Last Modified: 06 May 2020 11:01
URI: https://pred.uni-regensburg.de/id/eprint/19714

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