Kirovski, Georgi and Dorn, Christoph and Huber, Hanna and Moleda, Lukas and Niessen, Catrin and Wobser, Hella and Schacherer, Doris and Buechler, Christa and Wiest, Reiner and Hellerbrand, Claus (2011) Elevated systemic monocyte chemoattractrant protein-1 in hepatic steatosis without significant hepatic inflammation. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 91 (3). pp. 780-783. ISSN 0014-4800,
Full text not available from this repository. (Request a copy)Abstract
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and the metabolic syndrome. It encompasses a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). The latter develops upon pro-inflammatory cell infiltration and is widely considered as the first relevant pathophysiological step in NAFLD-progression. The chemokine monocyte chemoattractant protein 1 (MCP-1) plays an important role in the progression of hepatic inflammation and fibrosis, and both increased hepatic expression and circulating serum levels have been described in NASH. Here, we aimed to investigate MCP-1 expression in simple hepatic steatosis. Upon feeding a high-fat diet mice developed hepatic steatosis in the absence of significant hepatic inflammation, but elevated hepatic MCP-1 expression compared to control mice fed a standard chow. Interestingly, high-fat diet fed mice had significantly higher MCP-1 serum levels, and MCP-1 mRNA expression was significantly increased in visceral adipose tissue. Furthermore, MCP-1 serum levels were also elevated in patients with ultrasound-diagnosed NAFLD and correlated with the body-mass index and fasting glucose. In conclusion, our data indicate both the liver and adipose tissue as cellular sources of elevated circulating MCP-1 levels already in the early phase of hepatic steatosis. Since MCP-1 derived from visceral adipose tissue reaches the liver via portal circulation at high concentrations it may significantly contribute to the progression of simple steatosis to NASH. (C) 2011 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FATTY LIVER-DISEASE; METABOLIC SYNDROME; STELLATE CELLS; MACROPHAGE INFILTRATION; INSULIN-RESISTANCE; ADIPOSE-TISSUE; EXPRESSION; FIBROGENESIS; OBESITY; MCP-1; Adipose tissue; Chemokine; Hepatic steatosis; MCP-1; NAFLD; NASH |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 May 2020 08:50 |
| Last Modified: | 26 May 2020 08:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19738 |
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