Schlaier, Juergen Ralf and Habermeyer, Christine and Warnat, Jan and Lange, Max and Janzen, Annette and Hochreiter, Andreas and Proescholdt, Martin and Brawanski, Alexander and Fellner, Claudia (2011) Discrepancies between the MRI- and the electrophysiologically defined subthalamic nucleus. ACTA NEUROCHIRURGICA, 153 (12). pp. 2307-2318. ISSN 0001-6268,
Full text not available from this repository. (Request a copy)Abstract
The aim of our study was to evaluate discrepancies between the electrophysiologically and MRI-defined subthalamic nucleus (STN) in order to contribute to the ongoing debate of whether or not microelectrode recording (MER) provides additional information to image-guided targeting in deep brain stimulation. Forty-four STNs in 22 patients with Parkinson's disease were investigated. The three-dimensional MRI-defined STN was derived from segmentations of axial and coronal T2-weighted images. The electrophysiological STNs were generated from intraoperative MERs in 1,487 locations. The stereotactical coordinates of positive and negative STN recordings were re-imported to the planning software, where a three-dimensional reconstruction of the electrophysiological STN was performed and fused to the MRI data set. The estimated borders of the MRI- and MER-STN were compared. For statistical analysis Student's t, Mann-Whitney rank sum and Fisher's exact tests were used. MER-STN volumes, which were found outside the MRI-STN, ranged from 0 mm(3) to 87 mm(3) (mean: 45 mm(3)). A mean of 44% of the MER-STN volumes exceeded the MRI-STN (maximum: 85.1%; minimum: 15.1 %); 53.4% (n = 793) of the microelectrode recordings were concordant and 46.6% (n = 694) discordant with the MRI-defined anatomical STN. Regarding the dorsal borders, we found discrepancies between the MER- and MRI-STN of 0.27 mm (= mean; SD: 0.51 mm) on the first operated side and 1.51 mm (SD: 1.5 mm) on the second (p = 0.010, t-test). MER provides additional information to high-resolution anatomical MR images and may help to detect the amount and direction of brain shift.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEEP-BRAIN-STIMULATION; MAGNETIC-RESONANCE; PARKINSONS-DISEASE; MOVEMENT-DISORDERS; FUNCTIONAL NEUROSURGERY; GLOBUS-PALLIDUS; STEREOTACTIC LOCALIZATION; SHIFT; IMPLANTATION; SURGERY; Deep brain stimulation; Microelectrode recording; Subthalamic nucleus; Brain shift |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 May 2020 09:47 |
| Last Modified: | 26 May 2020 09:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19759 |
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