Bauer, Sabrina and Neumeier, Markus and Wanninger, Josef and Walter, Roland and Kopp, Andrea and Bala, Margarita and Schaeffler, Andreas and Buechler, Christa (2011) Systemic resistin is increased in type 2 diabetic patients treated with loop diuretics. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 25 (6). pp. 377-381. ISSN 1056-8727,
Full text not available from this repository. (Request a copy)Abstract
Increased serum resistin was found in rodent models of obesity and insulin resistance, whereas contradictory results have been obtained in human studies. In humans, resistin is primarily released by monocytes/macrophages, suggesting that soluble levels may be associated with macrophage activation. Here, systemic and monocyte-released resistin levels were found to be similar in type 2 diabetic (T2D) patients, overweight controls and normal-weight controls. When adjusted for body mass index and age, serum resistin modestly correlated with gamma-glutamyltransferase levels, fasting glucose and interleukin-6. Systemic resistin was marginally increased in T2D patients treated with beta-blockers or urate-lowering drugs and was considerably higher in patients treated with loop diuretics. Monocyte-released resistin was even reduced by the loop diuretic furosemide, excluding the possibility that this drug may directly stimulate resistin synthesis. In summary, the current data indicate that changes accompanying renal dysfunction but not obesity or type 2 diabetes are associated with increased serum resistin. (C) 2011 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESSENGER-RNA EXPRESSION; INSULIN-RESISTANCE; ADIPOSE-TISSUE; SERUM RESISTIN; PLASMA RESISTIN; MONONUCLEAR-CELLS; BLOOD MONOCYTES; SOLUBLE CD163; OBESITY; INFLAMMATION; Type 2 diabetes mellitus; Medication; Resistin; Monocyte |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 May 2020 06:01 |
| Last Modified: | 27 May 2020 06:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19834 |
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