Barth, Stephanie and Meister, Gunter and Graesser, Friedrich A. (2011) EBV-encoded miRNAs. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1809 (11-12). pp. 631-640. ISSN 1874-9399, 0006-3002
Full text not available from this repository. (Request a copy)Abstract
The Epstein-Barr virus (EBV) is an oncogenic Herpes virus involved in the induction of a variety of human tumours. It was the first virus found to encode microRNAs (miRNAs). MiRNAs are short, non-coding RNAs that in most cases negatively regulate gene expression at the post-transcriptional level. EBV-transformed cells express at least 44 mature viral miRNAs that target viral and cellular genes. In addition, EBV-infection severely deregulates the miRNA profile of the host cell. The presently available information indicates that the virus uses its miRNAs to inhibit the apoptotic response of the infected cell as a means to establish a latent infection. Likewise. EBV-encoded miRNAs interfere in the expression of viral genes in order to mask the infected cell from the immune response. Cellular targets of viral miRNAs are involved in protein traffic within the cell and regulate innate immunity. MiRNA profiling of diffuse large B-cell lymphoma (DLBCL) and nasal NK/T-cell lymphoma (NKTL) showed that only 2% of the miRNAs are derived from the virus, while viral miRNAs comprise up to 20% of the total miRNA in nasopharyngeal carcinoma (NPC) and probably contribute to the formation or maintenance of NPC. The presence of viral miRNAs in exosomes raises the fascinating possibility that virus-infected cells regulate gene expression in the surrounding tissue to avert destruction by the immune system. This article is part of a Special Issue entitled: MicroRNAs in viral gene regulation. (C) 2011 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPSTEIN-BARR-VIRUS; CELLULAR MICRORNA MIR-146A; HUMAN GAMMA-HERPESVIRUSES; MAREKS-DISEASE VIRUS; RNA-INTERFERENCE; B-CELLS; BURKITTS-LYMPHOMA; BINDING PROTEIN; GENE-EXPRESSION; NUCLEAR EXPORT; Epstein-Barr virus; EBV; MicroRNA; MiRNA; BHRF1; BART; Tumorigenesis; Transformation; Gene regulation; Apoptosis; Latency |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 May 2020 06:09 |
| Last Modified: | 27 May 2020 06:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19838 |
Actions (login required)
 |
View Item |
