Straub, Rainer H. (2011) Neuroendocrine immunology. New pathogenetic aspects and clinical application. ZEITSCHRIFT FUR RHEUMATOLOGIE, 70 (9). pp. 767-774. ISSN 0340-1855,
Full text not available from this repository. (Request a copy)Abstract
After two decades of enormous improvements in anti-inflammatory therapy with biologics long-standing disease sequelae in chronic inflammatory diseases CID) can be recognized, such as fatigue, anorexia/malnutrition, cachectic obesity, insulin resistance, dyslipidemia, changes of steroid hormone axes e. g. loss of androgens), increased sympathetic nervous tone/decreased parasympathetic nervous tone, inflammation-related anemia and osteopenia. This article demonstrates for the first time in the German language a new theory to explain the pathophysiology of these disease sequelae. It includes concepts from evolutionary medicine and neuroendocrine regulation of energy allocation. The core statement is: the networks of energy regulation and energy allocation have been evolutionarily positively selected for transient inflammatory episodes not for CIDs due to the negative selection pressure) but long-standing use of these adaptive programs for CID support systemic disease sequelae. These considerations might help to deviate focus from pure anti-inflammatory treatment to adequate diagnosis and therapy of systemic disease sequelae.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SICKLE-CELL-DISEASE; INFLAMMATORY DISEASES; VIRUS-INFECTION; PTPN22; Systemic immune disease; Systemic disease sequelae; Evolutionary medicine; Energy metabolism; Neuroendocrine immunology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 May 2020 06:51 |
| Last Modified: | 27 May 2020 06:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19850 |
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