Shamsara, Jamal and Behravan, Javad and Falsoleiman, Homa and Mohammadpour, Amir Hooshang and Rendeirs, Joerg and Ramezani, Mohammad (2011) Pentoxifylline administration changes protein expression profile of coronary artery disease patients. GENE, 487 (1). pp. 107-111. ISSN 0378-1119, 1879-0038
Full text not available from this repository. (Request a copy)Abstract
Increased level of inflammatory mediators plays a central role in the features of coronary artery diseases. As pentoxifylline could suppress the inflammatory process and has shown some promising beneficial effects in inflammatory diseases, we evaluated the effect of two months pentoxifylline administration in proteome of PBMCs of patients with coronary artery disease (CAD). A randomized placebo-controlled study was used. Fourteen CAD patients were randomized to 2 months of pentoxifyline treatment (1200 mg/day) (n = 7) or placebo treatment (n = 7). Blood samples were obtained before and after treatment. A comparative 2 dimensional gel electrophoresis was performed, and gels were silver-stained. Differentially expressed protein spots were detected and were identified by MALDI-TOF spectrometry. Six differentially expressed proteins were identified as HSP70, PPIA and alpha-Enolase, (all up-regulated) S100-A9, PIMT and beta-5 tubulin (all down-regulated), most of which had previously been shown to play a potential role in the pathogenesis of atherosclerosis. As the blood mononuclear cell proteome responds to pentoxifylline with changes in a number of atherosclerosis-relevant proteins, it seems that pentoxifylline could be a good choice for future studies for prevention of cardiovascular events. (C) 2011 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLOOD MONONUCLEAR-CELLS; SMOOTH-MUSCLE-CELLS; INFLAMMATORY MECHANISMS; OXIDATIVE STRESS; ATHEROSCLEROSIS; MONOCYTE; INTERVENTION; ATORVASTATIN; SIMVASTATIN; CYCLOPHILIN; Inflammation; PBMCs; Proteome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 May 2020 08:30 |
| Last Modified: | 27 May 2020 08:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19883 |
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