Beck, Hans Christian and Petersen, Jorgen and Felthaus, Oliver and Schmalz, Gottfried and Morsczeck, Christian (2011) Comparison of Neurosphere-like Cell Clusters Derived from Dental Follicle Precursor Cells and Retinal Muller Cells. NEUROCHEMICAL RESEARCH, 36 (11). pp. 2002-2007. ISSN 0364-3190,
Full text not available from this repository. (Request a copy)Abstract
Unrelated cells such as dental follicle precursor cells (DFPCs) and retinal Muller cells (MCs) make spheres after cultivation in serum-replacement medium (SRM). Until today, the relation and molecular processes of sphere formation from different cell types remain undescribed. Thus in this study we compared proteomes of spheres derived from MCs and DFPCs. 73% of 676 identified proteins were similar expressed in both cell types and many of them are expressed in the brain (55%). Moreover proteins are overrepresented that are associated with pathways for neural diseases such as Huntington disease or Alzheimer disease. Interestingly up-regulated proteins in DFPCs are involved in the biosynthesis of glycosphingolipids. These lipids are components of gangliosides such as GD3, which is a novel neural stem cell marker. In conclusion spheres from different types of cells have highly similar proteomes. These proteomes probably show essential cellular processes in neurosphere-like cell clusters.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIFFERENTIATION IN-VITRO; MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; PROGENITOR CELLS; NEURONAL DIFFERENTIATION; BIOMARKER; Dental follicle cells; Muller cells; Retinal progenitor cells; Neurospheres; Proteomics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 May 2020 09:55 |
| Last Modified: | 27 May 2020 09:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19910 |
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