Egan, C. E. and Maurer, K. J. and Cohen, S. B. and Mack, M. and Simpson, K. W. and Denkers, E. Y. (2011) Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection. MUCOSAL IMMUNOLOGY, 4 (6). pp. 658-670. ISSN 1933-0219,
Full text not available from this repository. (Request a copy)Abstract
Oral infection of C57BL/6 mice with Toxoplasma gondii triggers severe necrosis in the ileum within 7-10 days of infection. Lesion development is mediated by Th-1 cytokines, CD4(+) T cells, and subepithelial bacterial translocation. As such, these features share similarity to Crohn's disease. Recently, we uncovered a role for intraepithelial lymphocytes (IELs) in mediating pathology after Toxoplasma infection. We show here that alpha beta and not gamma delta T-cell IELs mediate intestinal damage. By adoptive transfer of mucosal T cells into naive Rag1(-/-) mice, we demonstrate that IELs do not function alone to cause inflammatory lesions, but act with CD4(+) T lymphocytes from the lamina propria (LP). Furthermore, recipient mice pretreated with broad-spectrum antibiotics to eliminate intestinal flora resisted intestinal disease after transfer of IELs and LP lymphocytes. Our data provide valuable new insights into the mechanisms of intestinal inflammation, findings that have important implications for understanding human inflammatory bowel disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOXOPLASMA-GONDII INFECTION; CROHNS-DISEASE; BOWEL-DISEASE; ORAL INFECTION; MURINE ILEITIS; NITRIC-OXIDE; PARASITE; PATHOGEN; IMMUNITY; GAMMA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 May 2020 10:17 |
| Last Modified: | 27 May 2020 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/19918 |
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