Edinger, Matthias and Hoffmann, Petra (2011) Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. CURRENT OPINION IN IMMUNOLOGY, 23 (5). pp. 679-684. ISSN 0952-7915
Full text not available from this repository. (Request a copy)Abstract
The adoptive transfer of donor-type CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) protects from graft-versus-host disease in murine bone marrow transplantation models. Results from first clinical trials exploring such strategies have recently been presented and seem to confirm the efficacy of Treg for the prevention of this severe complication after allogeneic stem cell transplantation. Further improvements in Treg isolation and in vitro expansion technologies will facilitate the broader exploration of Treg therapies, for example, for the treatment of ongoing graft-versus-host disease or the prevention of graft rejection after solid organ transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; TRANSCRIPTION FACTOR FOXP3; BONE-MARROW-TRANSPLANTATION; IN-VITRO EXPANSION; DNA METHYLATION; LYMPHOPROLIFERATIVE DISORDER; EPIGENETIC CONTROL; CUTTING EDGE; EXPRESSION; RAPAMYCIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 06 May 2020 06:42 |
| Last Modified: | 06 May 2020 06:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20016 |
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