Matsumoto, Kazumasa and Novara, Giacomo and Gupta, Amit and Margulis, Vitaly and Walton, Thomas J. and Roscigno, Marco and Ng, Casey and Kikuchi, Eiji and Zigeuner, Richard and Kassouf, Wassim and Fritsche, Hans-Martin and Ficarra, Vincenzo and Martignoni, Guido and Tritschler, Stefan and Carballido Rodriguez, Joaquin and Seitz, Christian and Weizer, Alon and Remzi, Mesut and Raman, Jay D. and Bolenz, Christian and Bensalah, Karim and Koppie, Theresa M. and Karakiewicz, Pierre I. and Wood, Christopher G. and Montorsi, Francesco and Iwamura, Masatsugu and Shariat, Shahrokh F. (2011) Racial differences in the outcome of patients with urothelial carcinoma of the upper urinary tract: an international study. BJU INTERNATIONAL, 108 (8B). E304-E309. ISSN 1464-4096,
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVE To assess the impact of differences in ethnicity on clinico-pathological characteristics and outcomes of patients with upper urinary tract urothelial carcinoma (UTUC) in a large multi-center series of patients treated with radical nephroureterectomy (RNU). MATERIALS AND METHODS We retrospectively collected the data of 2163 patients treated with RNU at 20 academic centres in America, Asia, and Europe. Univariable and multivariable Cox regression models addressed recurrence-free survival (RFS) and cancer-specific survival (CSS). RESULTS In all, 1794 (83%) patients were Caucasian and 369 (17%) were Japanese. All the main clinical and pathological features were significantly different between the two ethnicities. The median follow-up of the whole cohort was 36 months. At last follow-up, 554 patients (26%) developed disease recurrence and 461 (21%) were dead from UTUC. The 5-year RFS and CSS estimates were 71.5% and 74.2%, respectively, for Caucasian patients compared with 68.8% and 75.4%, respectively, for Japanese patients. On univariable Cox regression analyses, ethnicity was not significantly associated with either RFS (P = 0.231) or CSS (P = 0.752). On multivariable Cox regression analyses that adjusted for the effects of age, gender, surgical type, T stage, grade, tumour architecture, presence of concomitant carcinoma in situ, lymphovascular invasion, tumour necrosis, and lymph node status, ethnicity was not associated with either RFS (hazard ratio [HR] 1.1; P = 0.447) or CSS (HR 1.0; P = 0.908). CONCLUSIONS There were major differences in the clinico-pathological characteristics of Caucasian and Japanese patients. However, RFS and CSS probabilities were not affected by ethnicity and race was not an independent predictor of either recurrence or cancer-related death.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLADDER-CANCER; RADICAL NEPHROURETERECTOMY; ONCOLOGIC OUTCOMES; MORTALITY; SURVIVAL; DIAGNOSIS; DISPARITY; GENDER; EXTENT; race; prognosis; urinary tract cancer; urothelial carcinoma; nephroureterectomy; recurrence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 May 2020 07:46 |
| Last Modified: | 28 May 2020 07:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20028 |
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