May, Matthias and Bastian, Patrick J. and Burger, Maximilian and Bolenz, Christian and Trojan, Lutz and Herrmann, Edwin and Wuelfing, Christian and Mueller, Stefan C. and Ellinger, Joerg and Buchner, Alexander and Stief, Christian G. and Tilki, Derya and Otto, Wolfgang and Hoefner, Thomas and Hohenfellner, Markus and Haferkamp, Axel and Roigas, Jan and Zacharias, Mario and Wieland, Wolf F. and Fritsche, Hans-Martin (2011) Multicenter evaluation of the prognostic value of pT0 stage after radical cystectomy due to urothelial carcinoma of the bladder. BJU INTERNATIONAL, 108 (8B). E278-E283. ISSN 1464-4096,
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVE To evaluate the characteristics and long-term outcome of patients with pT0 stage after radical cystectomy (RC) for urothelial carcinoma of the urinary bladder (UCB). PATIENTS AND METHODS Clinical and pathological records of 2403 patients treated with RC for UCB were collected in a multi-institutional database. The patients met the following criteria: clinical tumour stage cTa-cT2, cN0, cM0, no neoadjuvant chemotherapy or radiotherapy. Overall (OS) and cancer-specific survival rates (CSS) were calculated for the various clinical tumour stages in relation to their corresponding pathological tumour stage in the RC sample. Further to this, a multivariable prediction model was developed based onthe available clinical data to estimate the probability of tumour stage pT0. RESULTS The mean follow-up was 53 months and 132 patients (5.5%) were stage pT0. Patients withstage cT2-pT0 had a 5-year CSS of 87% vs 69% for cT2-pT2 (P = 0.012) and 57% for cT2-pT + (P < 0.001). In a multivariable Cox-model, stage pT0 led to a significant reduction of cancer-specific mortality (hazard ratio0.27; 95% confidence interval 0.12-0.61). A logistical regression model identified clinical tumour stage (advantage for non-invasive stages) and transurethral resection of the urinary bladder (TURB) time frame (advantage for more recent surgery) as independent predictors for stage pT0. CONCLUSIONS In muscle-invasive clinical tumour stages, patients with pathological tumour stage pT0 form a subgroup showing a significantly better CSS. A radical TURB is, assumedly, not causative of this improved survival rate, but rather it is that individual tumour characteristics allow for complete tumour eradication through the TURB procedure. A TURB with R0 resection is, as such, only a sign of a better tumour prognosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEOADJUVANT CHEMOTHERAPY; LONG-TERM; CANCER; SURVIVAL; SPECIMEN; THERAPY; TUMORS; RISK; urothelial carcinoma; bladder cancer; radical cystectomy; pT0 stage |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 May 2020 07:52 |
| Last Modified: | 28 May 2020 07:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20029 |
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