Perreau, Matthieu and Welles, Hugh C. and Harari, Alexandre and Hall, Olivia and Martin, Ricardo and Maillard, Michel and Dorta, Gian and Bart, Pierre-Alexandre and Kremer, Eric J. and Tartaglia, Jim and Wagner, Ralf and Esteban, Mariano and Levy, Yves and Pantaleo, Giuseppe (2011) DNA/NYVAC Vaccine Regimen Induces HIV-Specific CD4 and CD8 T-Cell Responses in Intestinal Mucosa. JOURNAL OF VIROLOGY, 85 (19). pp. 9854-9862. ISSN 0022-538X,
Full text not available from this repository. (Request a copy)Abstract
In the present study, we have investigated the anatomic distribution in blood and gut mucosal tissues of memory poxvirus-specific CD4 and CD8 T cells in subjects vaccinated with smallpox and compared it with vector (NYVAC)-specific and HIV insert-specific T-cell responses induced by an experimental DNA-C/NYVAC-C vaccine regimen. Smallpox-specific CD4 T-cell responses were present in the blood of 52% of the subjects studied, while smallpox-specific CD8 T cells were rarely detected (12%). With one exception, smallpox-specific T cells were not measurable in gut tissues. Interestingly, NYVAC vector-specific and HIV-specific CD4 and CD8 T-cell responses were detected in almost 100% of the subjects immunized with DNA-C/NYVAC-C in blood and gut tissues. The large majority (83%) of NYVAC-specific CD4 T cells expressed alpha 4 beta 7 integrins and the HIV coreceptor CCR5. These results demonstrate that the experimental DNA-C/NYVAC-C HIV vaccine regimen induces the homing of potentially protective HIV-specific CD4 and CD8 T cells in the gut, the port of entry of HIV and one of the major sites for HIV spreading and the depletion of CD4 T cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THYMUS-EXPRESSED CHEMOKINE; ADENOVIRUS VECTORS; DENDRITIC CELLS; IMMUNE-SYSTEM; RECEPTOR CCR9; CLADE-C; MEMORY; STEP; IMMUNOGENICITY; LYMPHOCYTES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 May 2020 09:07 |
| Last Modified: | 28 May 2020 09:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20044 |
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