Kiefer, F. and Witt, S. H. and Frank, J. and Richter, A. and Treutlein, J. and Lemenager, T. and Noethen, M. M. and Cichon, S. and Batra, A. and Berner, M. and Wodarz, N. and Zimmermann, U. S. and Spanagel, R. and Wiedemann, K. and Smolka, M. N. and Heinz, A. and Rietschel, M. and Mann, K. (2011) Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. PHARMACOGENOMICS JOURNAL, 11 (5). pp. 368-374. ISSN 1470-269X,
Full text not available from this repository. (Request a copy)Abstract
In alcoholism, both relapse to alcohol drinking and treatment response are suggested to be genetically modulated. This study set out to determine whether the top 15 single nucleotide polymorphisms (SNPs) of a recent genome-wide association (GWA) and follow-up study of alcohol dependence are associated with relapse behavior and pharmacological treatment response in 374 alcohol-dependent subjects who underwent a randomized, double-blind, placebo-controlled trial with acamprosate, naltrexone or placebo. The single nucleotide polymorphism, rs13273672, an intronic SNP in the gene for GATA-binding protein 4 (GATA4), was associated with relapse within the 90-day medical treatment period (P<0.01). Subsequent pharmacogenetic analyses showed that this association was mainly based on patients treated with acamprosate (P<0.01). In line with the observation that natriuretic peptide promoters are modulated by GATA4, a significant gene dose effect on the variance of atrial natriuretic peptide (ANP) plasma concentration in the different GATA4 genotypes (P<0.01) was found. Hence, genetic variations in GATA4 might influence relapse and treatment response to acamprosate in alcohol-dependent patients via modulation of ANP plasma levels. These results could help to identify those alcohol-dependent patients who may be at an increased risk of relapse and who may better respond to treatment with acamprosate. The Pharmacogenomics Journal (2011) 11, 368-374; doi:10.1038/tpj.2010.51; published online 29 June 2010
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIAC TRANSCRIPTION; ADDICTIVE BEHAVIOR; ASSOCIATION; WITHDRAWAL; VALIDATION; EXPRESSION; PREVENTION; PREFERENCE; PROMOTERS; GENETICS; genetic association study; alcohol; GATA4; atrial natriuretic peptide; acamprosate |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 07:06 |
| Last Modified: | 02 Jun 2020 07:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20073 |
Actions (login required)
 |
View Item |
