Kees, Martin G. and Weber, Susanne and Kees, Frieder and Horbach, Thomas (2011) Pharmacokinetics of moxifloxacin in plasma and tissue of morbidly obese patients. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 66 (10). pp. 2330-2335. ISSN 0305-7453,
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Objectives: To assess the pharmacokinetics of moxifloxacin in morbidly obese patients. Methods: Twelve morbidly obese patients (2 male/10 female, age 25-61 years, weight 98-166 kg, body mass index 43.0-58.2 kg/m(2)) scheduled for gastric bypass surgery were treated with 400 mg of moxifloxacin orally once daily for 3 days and with 400 mg of moxifloxacin intravenously on day 4 (day of surgery). Pharmacokinetic analysis was performed on day 1 and day 4. Specimens of small intestine, greater omentum and subcutaneous adipose tissue were collected intraoperatively 1.8-3.7 h after moxifloxacin infusion. Moxifloxacin concentrations were determined by HPLC. Results: The plasma pharmacokinetics (mean +/- SD) was comparable to historical data in normal-weight subjects. Oral bioavailability was 79.6% +/- 11.5%. After intravenous administration, plasma clearance was 9.6 +/- 2.0 L/h, volume of distribution was 165 +/- 30 L and area under the curve was 43.7 +/- 11.8 mg.h/L. Linear regression analysis showed the volume of distribution to be better correlated with ideal body weight, lean body weight, fat-free mass or height (R(2) = 0.60-0.67, P = 0.001-0.003) than with total body weight (R(2) = 0.46, P = 0.015). Whereas mean tissue concentrations in small intestine (6.99 +/- 2.34 mg/kg) were twice the concomitant plasma concentrations, the concentrations in greater omentum (0.801 +/- 0.168 mg/kg) or subcutaneous fat (0.638 +/- 0.180 mg/kg) were only one-quarter of those. Conclusions: The pharmacokinetics of moxifloxacin is not significantly affected by morbid obesity. No dose adjustment seems to be necessary in this particular population.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY-TRACT INFECTIONS; ADULT PATIENTS; 400 MG; PENETRATION; CIPROFLOXACIN; DISPOSITION; fluoroquinolones; volume of distribution; size descriptor; HPLC |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Frieder Kees |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 May 2020 06:53 |
| Last Modified: | 29 May 2020 06:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20132 |
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