Lukas, Michael and Toth, Iulia and Reber, Stefan O. and Slattery, David A. and Veenema, Alexa H. and Neumann, Inga D. (2011) The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice. NEUROPSYCHOPHARMACOLOGY, 36 (11). pp. 2159-2168. ISSN 0893-133X, 1740-634X
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Social avoidance and social phobia are core symptoms of various psychopathologies but their underlying etiology remains poorly understood. Therefore, this study aims to reveal pro-social effects of the neuropeptide oxytocin (OT), under both basal and stress-induced social avoidance conditions in rodents using a social preference paradigm. We initially show that intracerebroventricular (i.c.v.) application of an OT receptor antagonist (OTR-A) in naive male rats (0.75 mu g/5 mu l), or mice (20 mu g/2 mu l), reduced social exploration of a novel con-specific indicative of attenuated social preference. Previous exposure of male rats to a single social defeat resulted in loss of their social preference and social avoidance, which could be restored by i.c.v. infusion of synthetic OT (0.1 mu g/5 mu l) 20 min before the social preference test. Although the amygdala has been implicated in both social and OT-mediated actions, bilateral OTR-A (0.1 mu g/1 mu l) or OT (0.01 mu g/1 mu l) administration into various subnuclei of the amygdala did not affect basal or stress-induced social preference behavior, respectively. Finally, we demonstrate the social specificity of these OT-mediated effects by showing that neither an arginine vasopressin V1a receptor antagonist (0.75 mu g/5 mu l, i.c.v.) nor the anxiogenic drug pentylenetetrazol (15 mg/kg, i.p.) altered social preference, with OTR-A not affecting non-social anxiety on the elevated plus-maze. Overall, the data indicate that the basal activity of the endogenous brain OT system is sufficient to promote natural occurring social preference in rodents while synthetic OT shows potential to reverse stress-induced social avoidance and might thus be of use for treating social phobia and social dysfunction in humans. Neuropsychopharmacology (2011) 36, 2159-2168; doi: 10.1038/npp.2011.95;published online 15 June 2011
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AUTISM SPECTRUM DISORDERS; PITUITARY-ADRENAL AXIS; FEMALE PRAIRIE VOLES; VASOPRESSIN RELEASE; BRAIN OXYTOCIN; PARAVENTRICULAR NUCLEUS; MEDIAL AMYGDALA; MICROTUS-OCHROGASTER; INTERMALE AGGRESSION; INTRANASAL OXYTOCIN; social preference; social interaction; social defeat; amygdala; vasopressin; anxiety |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 May 2020 08:38 |
| Last Modified: | 29 May 2020 08:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20140 |
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