Hartl, Janine and Scherer, Marcus N. and Loss, Martin and Schnitzbauer, Andreas and Farkas, Stefan and Baier, Lucia and Szecsey, Alexander and Schoelmerich, Juergen and Schlitt, Hans-Juergen and Kirchner, Gabriele I. (2011) Strong predictors for alcohol recidivism after liver transplantation: Non-acceptance of the alcohol problem and abstinence of < 3 months. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 46 (10). pp. 1257-1266. ISSN 0036-5521, 1502-7708
Full text not available from this repository. (Request a copy)Abstract
Objective. Alcohol-toxic liver cirrhosis (ALC) is one of the main indications for liver transplantation (LT). The aim of the study is to define predictors for alcohol recidivism and to identify the outcome and quality of life of such patients. Material and methods. From March 2003 to July 2009, 226 patients underwent LT in our centre. In 53% liver cirrhosis was caused by alcohol abuse (sole/cofactor). Outcome and alcohol recidivism were assessed using patients' records, laboratory tests and interviews (patient, family members and family doctor). Furthermore, patients received an SF-36 quality of life and a self-designed questionnaire anonymously. Results. Mean follow-up after LT was 31 + 23 months. The 5-year survival rate after LT in patients with ALC was significantly better compared to patients with other indications (78 vs. 64%; p = 0.016). Quality of life of both patient groups was comparable. After LT, alcohol recidivism rate was 16%. Patients with an alcohol abstinence of < 3 months before LT had a significantly higher (p = 0.012) rate of alcohol recidivism in comparison to those with an abstinence of > 3 months. Another predictor for alcohol recidivism was the patients' non-acceptance of having an alcohol problem before LT (p = 0.001). Conclusions. ALC is a good indication for LT. An alcohol abstinence of < 3 months before LT and a non-acceptance of having an alcohol problem are strong predictors for alcohol recidivism after LT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TERM-FOLLOW-UP; DISEASE; RELAPSE; DRINKING; CONSUMPTION; MANAGEMENT; SURVIVAL; CRITERIA; EUROPE; IMPACT; Alcohol recidivism; alcoholic liver disease; liver transplantation; predictors; quality of life |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 May 2020 08:40 |
| Last Modified: | 29 May 2020 08:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20141 |
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