Genkinger, Jeanine M. and Spiegelman, Donna and Anderson, Kristin E. and Bernstein, Leslie and van den Brandt, Piet A. and Calle, Eugenia E. and English, Dallas R. and Folsom, Aaron R. and Freudenheim, Jo L. and Fuchs, Charles S. and Giles, Graham G. and Giovannucci, Edward and Horn-Ross, Pamela L. and Larsson, Susanna C. and Leitzmann, Michael and Mannisto, Satu and Marshall, James R. and Miller, Anthony B. and Patel, Alpa V. and Rohan, Thomas E. and Stolzenberg-Solomon, Rachael Z. and Verhage, Bas A. J. and Virtamo, Jarmo and Willcox, Bradley J. and Wolk, Alicja and Ziegler, Regina G. and Smith-Warner, Stephanie A. (2011) A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. INTERNATIONAL JOURNAL OF CANCER, 129 (7). pp. 1708-1717. ISSN 0020-7136,
Full text not available from this repository. (Request a copy)Abstract
Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2), pancreatic cancer risk was 47% higher (95% CI:23-75%) among obese (BMI >= 30 kg/m(2)) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI >= 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2)). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m(2)) and not obese at baseline (BMI < 30 kg/m(2)), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI >= 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BODY-MASS INDEX; LARGE US COHORT; PHYSICAL-ACTIVITY; ALCOHOL-CONSUMPTION; UNITED-STATES; GLYCEMIC INDEX; OBESITY; WEIGHT; HEIGHT; WOMEN; pancreatic cancer; anthropometry; pooled analysis; deceased |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 May 2020 10:36 |
| Last Modified: | 29 May 2020 10:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20150 |
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