Seifarth, Christian and Littmann, Leonie and Resheq, Yazid and Roessner, Susanne and Goldwich, Andreas and Pangratz, Nadine and Kerek, Franz and Steinkasserer, Alexander and Zinser, Elisabeth (2011) MCS-18, a novel natural plant product prevents autoimmune diabetes. IMMUNOLOGY LETTERS, 139 (1-2). pp. 58-67. ISSN 0165-2478,
Full text not available from this repository. (Request a copy)Abstract
There is still a vital need for new therapies in order to prevent or treat type I diabetes. In this respect, we report that MCS-18 a novel natural product isolated from the plant Helleborus purpurascens (i.e. Christmas rose) is able to increase diabetes free survival using the NOD-mouse model, which is accompanied with a diminished IFN-gamma secretion of splenocytes. In the animal group which has been treated with MCS-18 during week 8 and week 12 of age 70% of the animals showed a diabetes free survival at week 30, whereas in contrast in the untreated animals less than 10% were free of diabetes. MCS-18 treatment significantly reduced islet T-cell infiltrates as well as the rate of T-cell proliferation. Peninsular infiltrates in the MCS-18 treated animals showed a significantly enhanced number of Foxp3(+) CD25(+) T cells, indicating the increased presence of regulatory T cells. These studies show that MCS-18 exerts an efficient immunosuppressive activity with remarkable potential for the therapy of diseases characterized by pathological over-activation of the immune system. (C) 2011 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; DENDRITIC CELLS; HELLEBORUS-PURPURASCENS; BONE-MARROW; NOD MOUSE; IN-VIVO; INSULIN; MELLITUS; ANTIBODY; MODEL; Autoimmunity; Diabetes; Regulatory T cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 May 2020 10:41 |
| Last Modified: | 29 May 2020 10:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20154 |
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