Heid, I. M. and Winkler, T. W. and Grassmann, F. and Weber, B. H. F. (2011) How big are the small genetic risks? MEDIZINISCHE GENETIK, 23 (3). pp. 377-384. ISSN 1863-5490,
Full text not available from this repository.Abstract
While family studies are ideal to pinpoint strong genetic risk effects, genome-wide association studies in unrelated individuals are particularly successful in identifying moderate and small genetic risks for multifactorial diseases and disease-relevant quantitative parameters. Here, we present how the genetic risk for such variants is computed and what models are used to derive cumulative genetic risk. Using the examples of obesity, diabetes, and age-related macular degeneration, we illustrate how these risks are computed and tackle the question of how big the small genetic risks are.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMPLEMENT FACTOR-H; MACULAR DEGENERATION; PREDICTION; LOCI; Genetic association studies; Risk assessment; Linear models; Obesity; Age-related macular degeneration |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 04:38 |
| Last Modified: | 02 Jun 2020 04:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20193 |
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