Erdel, Fabian and Krug, Jana and Laengst, Gernot and Rippe, Karsten (2011) Targeting chromatin remodelers: Signals and search mechanisms. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1809 (9). pp. 497-508. ISSN 1874-9399, 0006-3002
Full text not available from this repository. (Request a copy)Abstract
Chromatin remodeling complexes are ATP-driven molecular machines that change chromatin structure by translocating nucleosomes along the DNA, evicting nucleosomes, or changing the nucleosomal histone composition. They are highly abundant in the cell and numerous different complexes exist that display distinct activity patterns. Here we review chromatin-associated signals that are recognized by remodelers. It is discussed how these regulate the remodeling reaction via changing the nucleosome substrate/product binding affinity or the catalytic translocation rate. Finally, we address the question of how chromatin remodelers operate in the cell nucleus to find specifically marked nucleosome substrates via a diffusion driven target location mechanism, and estimate the search times of this process. This article is part of a Special Issue entitled:Snf2/Swi2 ATPase structure and function. (C) 2011 Elsevier BM. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EMBRYONIC STEM-CELLS; RIBOSOMAL-RNA GENES; POLYMERASE-I TRANSCRIPTION; HISTONE VARIANT H3.3; STRAND BREAK REPAIR; DNA-DAMAGE; COMPLEX NORC; ANOMALOUS DIFFUSION; PROTEIN EXPRESSION; NEURAL DEVELOPMENT; Chromatin remodeling; Nucleosome translocation; Histone modifications; Diffusion-controlled target location |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst |
| Depositing User: | Petra Gürster |
| Date Deposited: | 05 May 2020 06:37 |
| Last Modified: | 05 May 2020 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20245 |
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