Taurines, Regina and Gruenblatt, Edna and Schecklmann, Martin and Schwenck, Christina and Albantakis, Laura and Reefschlaeger, Lennart and Walitza, Susanne and Renner, Tobias and Gerlach, Manfred and Thome, Johannes and Romanos, Marcel (2011) Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 12. pp. 104-108. ISSN 1562-2975,
Full text not available from this repository. (Request a copy)Abstract
Objectives. In absence of objective clinical characteristics the identification of peripheral biomarkers in neuropsychiatric disorders is highly relevant for the diagnostic process and an individualized therapy. We analyzed mRNA-expression of monoaminergic candidate genes (DRD4, DRD5, TPH1) in peripheral tissue of patients with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD), highly comorbid with ADHD, searching for possible molecular markers for these disorders. Methods. mRNA was obtained from children and adolescents with ADHD (n = 51) and ASD (n = 26), diagnosed according to ICD-10 criteria, as well as healthy controls (n = 39). mRNA expression was determined via quantitative realtime PCR (qRT-PCR) from whole blood cells. Results. The concentrations of DRD4-mRNA in the whole blood were significantly lower in ADHD and ASD children (19 of 26 comorbid with ADHD) compared to healthy controls. ASD patients revealed a significantly decreased DRD5 mRNA expression in comparison to the two other groups. Conclusions. Alterations in mRNA expression patterns provide further evidence for a relevant effect of the respective candidate genes in the pathophysiology of ADHD. Given their potential as biomarkers mRNA expression patterns may be useful tools in (differential-) diagnostic procedures of ADHD and ASD. Future studies may determine the sensitivity and specificity of these putative biomarkers in larger samples including further neuropsychiatric diagnoses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEFICIT/HYPERACTIVITY DISORDER; PERIPHERAL MARKER; LYMPHOCYTES; SCHIZOPHRENIA; NEUROBIOLOGY; INDIVIDUALS; ASSOCIATION; VARIANTS; DRD4; mRNA expression; attention deficit hyperactivity disorder (ADHD); autism spectrum disorder (ASD); dopamine receptor D4, D5 (DRD4, DRD5) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2020 06:22 |
| Last Modified: | 02 Jun 2020 06:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20303 |
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